C.J. Spiller ran the 40-yard dash in 4.27 seconds at the 2010 NFL Combine. This is one of the fastest times ever recorded. Spiller weighed 196 pounds when he achieved this feat. Fast forward to the 2018 Combine, in which Saquon Barkley ran the 40 in 4.4 seconds, and one may question which time is better.